Hallmarks of peripheral nerve function in bone regeneration

R Tao, B Mi, Y Hu, S Lin, Y **ong, X Lu, AC Panayi… - Bone research, 2023‏ - nature.com
Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

[HTML][HTML] Bioelectronic medicine: preclinical insights and clinical advances

VA Pavlov, KJ Tracey - Neuron, 2022‏ - cell.com
The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …

Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation

G Valle, N Katic Secerovic, D Eggemann… - Nature …, 2024‏ - nature.com
Artificial communication with the brain through peripheral nerve stimulation shows promising
results in individuals with sensorimotor deficits. However, these efforts lack an intuitive and …

Highly-stable, injectable, conductive hydrogel for chronic neuromodulation

M Yang, L Wang, W Liu, W Li, Y Huang, Q **… - Nature …, 2024‏ - nature.com
Electroceuticals, through the selective modulation of peripheral nerves near target organs,
are promising for treating refractory diseases. However, the small sizes and the delicate …

Strategies for precision vagus neuromodulation

U Ahmed, YC Chang, S Zafeiropoulos… - Bioelectronic …, 2022‏ - Springer
The vagus nerve is involved in the autonomic regulation of physiological homeostasis,
through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of …

[HTML][HTML] Organ-and function-specific anatomical organization of vagal fibers supports fascicular vagus nerve stimulation

N Jayaprakash, W Song, V Toth, A Vardhan, T Levy… - Brain stimulation, 2023‏ - Elsevier
Vagal fibers travel inside fascicles and form branches to innervate organs and regulate
organ functions. Existing vagus nerve stimulation (VNS) therapies activate vagal fibers non …

Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications

D Carnevale - Nature Reviews Cardiology, 2022‏ - nature.com
Cardiovascular diseases (CVDs) make a substantial contribution to the global burden of
disease. Prevention strategies have succeeded in reducing the effect of acute CVD events …

Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel?

S Zafeiropoulos, U Ahmed, A Bikou, IT Mughrabi… - Trends in cardiovascular …, 2024‏ - Elsevier
Autonomic dysfunction and chronic inflammation contribute to the pathogenesis and
progression of several cardiovascular diseases (CVD), such as heart failure with preserved …

Reflex regulation of systemic inflammation by the autonomic nervous system

RM McAllen, MJ McKinley, D Martelli - Autonomic Neuroscience, 2022‏ - Elsevier
This short review focusses on the inflammatory reflex, which acts in negative feedback
manner to moderate the inflammatory consequences of systemic microbial challenge. The …

Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension

S Zafeiropoulos, U Ahmed, A Bekiaridou… - Circulation …, 2024‏ - ahajournals.org
BACKGROUND: Inflammation is pathogenically implicated in pulmonary arterial
hypertension; however, it has not been adequately targeted therapeutically. We investigated …