Recent advancements in gene supplementation therapy are expanding the options for the
treatment of neurological disorders. Among the available delivery vehicles, adeno …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Cre/loxP technology has revolutionized genetic studies and allowed for spatial and temporal
control of gene expression in specific cell types. Microglial biology has particularly benefited …

With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical
need to identify, target and manipulate specific cell populations expressing the mu-opioid …

Adeno-associated virus (AAV) is a promising in vivo gene delivery platform showing
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …

The brain is often described as an" immune-privileged" organ due to the presence of the
blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial …

Recent discoveries of rare variants of human APOE may shed light on novel therapeutic
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …

Microglia are multifaceted cells that act as immune sentinels, with important roles in
pathological events, but also as integral contributors to the normal development and function …

Lactate-derived histone lactylation is involved in multiple pathological processes through
transcriptional regulation. The role of lactate-derived histone lactylation in the repair of …

Tissue macrophages, including microglia, are notoriously resistant to genetic manipulation.
Here, we report the creation of Adeno-associated viruses (AAV) variants that efficiently and …