Host-directed therapies: modulating inflammation to treat tuberculosis

S Krug, S Parveen, WR Bishai - Frontiers in immunology, 2021 - frontiersin.org
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Combination therapy with charged particles and molecular targeting: a promising avenue to overcome radioresistance

K Konings, C Vandevoorde, B Baselet… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades,
remarkable technological progress has been made in the field of conventional radiotherapy …

p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells

P Dey, S Biswas, R Das, S Chatterjee… - … and Biophysical Research …, 2023 - Elsevier
The Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib gives promising
results against various types of cancers in clinical trials. The combination of drugs always …

Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by …

P Chowdhury, P Dey, S Ghosh, A Sarma, U Ghosh - BMC cancer, 2019 - Springer
Background Carbon ion (12 C) radiotherapy is becoming very promising to kill highly
metastatic cancer cells kee** adjacent normal cells least affected. Our previous study …

The parp enzyme family and the hallmarks of cancer part 2: hallmarks related to cancer host interactions

MA Demény, L Virág - Cancers, 2021 - mdpi.com
Simple Summary Members of the poly (ADP-ribose)-polymerase (PARP) enzyme family
regulate a broad range of cellular functions related to carcinogenesis, tumor growth, cell …

[HTML][HTML] Basic and translational research on carbon-ion radiobiology

S Sai, M Koto, S Yamada - American Journal of Cancer Research, 2023 - ncbi.nlm.nih.gov
Carbon-ion beam irradiation (IR) has evident advantages over the conventional photon
beams in treating tumors. It releases enormous amount of energy in a well-defined range …

Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation

M Césaire, U Ghosh, JB Austry, E Muller… - Journal of Bone …, 2019 - Elsevier
Chondrosarcoma is a malignant tumor that arises from cartilaginous tissue and is
radioresistant and chemoresistant to conventional treatments. The preferred treatment …

Leaf Extract and Active Fractions of Dillenia pentagyna Roxb. Reduce In Vitro Human Cancer Cell Migration Via NF-κB Pathway

D De, P Chowdhury, SK Panda… - Integrative Cancer …, 2022 - journals.sagepub.com
Background: Different parts of Dillenia pentagyna have long been used in traditional
medicines to cure several diseases including cancer. However, the mechanism (s) of anti …

A new platinum-based prodrug candidate for chemotherapy and its synergistic effect with hadrontherapy: novel strategy to treat glioblastoma

B Ferrari, E Roda, EC Priori, F De Luca… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common tumor of the central nervous system. Current
therapies, often associated with severe side effects, are inefficacious to contrast the GBM …

Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation

P Srivastava, A Sarma, CM Chaturvedi - PLoS One, 2018 - journals.plos.org
High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used
as a method for advanced radiotherapy in the treatment of cancer. It has many advantages …