Host-directed therapies: modulating inflammation to treat tuberculosis
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
Combination therapy with charged particles and molecular targeting: a promising avenue to overcome radioresistance
K Konings, C Vandevoorde, B Baselet… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades,
remarkable technological progress has been made in the field of conventional radiotherapy …
remarkable technological progress has been made in the field of conventional radiotherapy …
p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells
P Dey, S Biswas, R Das, S Chatterjee… - … and Biophysical Research …, 2023 - Elsevier
The Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib gives promising
results against various types of cancers in clinical trials. The combination of drugs always …
results against various types of cancers in clinical trials. The combination of drugs always …
Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by …
Background Carbon ion (12 C) radiotherapy is becoming very promising to kill highly
metastatic cancer cells kee** adjacent normal cells least affected. Our previous study …
metastatic cancer cells kee** adjacent normal cells least affected. Our previous study …
The parp enzyme family and the hallmarks of cancer part 2: hallmarks related to cancer host interactions
MA Demény, L Virág - Cancers, 2021 - mdpi.com
Simple Summary Members of the poly (ADP-ribose)-polymerase (PARP) enzyme family
regulate a broad range of cellular functions related to carcinogenesis, tumor growth, cell …
regulate a broad range of cellular functions related to carcinogenesis, tumor growth, cell …
[HTML][HTML] Basic and translational research on carbon-ion radiobiology
S Sai, M Koto, S Yamada - American Journal of Cancer Research, 2023 - ncbi.nlm.nih.gov
Carbon-ion beam irradiation (IR) has evident advantages over the conventional photon
beams in treating tumors. It releases enormous amount of energy in a well-defined range …
beams in treating tumors. It releases enormous amount of energy in a well-defined range …
Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation
M Césaire, U Ghosh, JB Austry, E Muller… - Journal of Bone …, 2019 - Elsevier
Chondrosarcoma is a malignant tumor that arises from cartilaginous tissue and is
radioresistant and chemoresistant to conventional treatments. The preferred treatment …
radioresistant and chemoresistant to conventional treatments. The preferred treatment …
Leaf Extract and Active Fractions of Dillenia pentagyna Roxb. Reduce In Vitro Human Cancer Cell Migration Via NF-κB Pathway
D De, P Chowdhury, SK Panda… - Integrative Cancer …, 2022 - journals.sagepub.com
Background: Different parts of Dillenia pentagyna have long been used in traditional
medicines to cure several diseases including cancer. However, the mechanism (s) of anti …
medicines to cure several diseases including cancer. However, the mechanism (s) of anti …
A new platinum-based prodrug candidate for chemotherapy and its synergistic effect with hadrontherapy: novel strategy to treat glioblastoma
B Ferrari, E Roda, EC Priori, F De Luca… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common tumor of the central nervous system. Current
therapies, often associated with severe side effects, are inefficacious to contrast the GBM …
therapies, often associated with severe side effects, are inefficacious to contrast the GBM …
Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation
P Srivastava, A Sarma, CM Chaturvedi - PLoS One, 2018 - journals.plos.org
High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used
as a method for advanced radiotherapy in the treatment of cancer. It has many advantages …
as a method for advanced radiotherapy in the treatment of cancer. It has many advantages …