Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach
RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …
[HTML][HTML] Nano-encapsulation and conjugation applied in the development of lipid nanoparticles delivering nucleic acid materials to enable gene therapies
L Dinh, L Mahon, B Yan - Applied Nano, 2024 - mdpi.com
Nano-encapsulation and conjugation are the main strategies employed for drug delivery.
Nanoparticles help improve encapsulation and targeting efficiency, thus optimizing …
Nanoparticles help improve encapsulation and targeting efficiency, thus optimizing …
Golden Threads of Lipid Nanoparticles (LNPs) contributing to COVID-19 mRNA Vaccine: A Review
M Vasu, P Yadav, Y Satyanarayana, J Ahlawat… - BioNanoScience, 2024 - Springer
Lipid-based RNA delivery techniques, particularly lipid nanoparticles (LNPs), have
generated significant scientific interest, primarily because of their distinct attributes including …
generated significant scientific interest, primarily because of their distinct attributes including …
Current Advances in Non-viral Nanoparticle-Based Gene Therapy for Effective Management of Cancer.
The unique potential of gene therapy can precisely target the oncogenes and emerge as an
effective, prevalent treatment for cancer therapy. Current innovations in genetic science and …
effective, prevalent treatment for cancer therapy. Current innovations in genetic science and …
Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine
Pyroptosis, a form of programmed cell death characterized by cell lysis and inflammation,
has significant implications for disease treatment. Nanomaterials (NMs), with their unique …
has significant implications for disease treatment. Nanomaterials (NMs), with their unique …
Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue
RA Foley, PG Ayoub, V Sinha, C Juett, A Sanoyca… - bioRxiv, 2025 - biorxiv.org
We report the engineering of lipid nanoparticles (LNPs) to transport CRISPR/Cas9 payloads,
including double-stranded DNA (dsDNA) donor templates, designed for homology directed …
including double-stranded DNA (dsDNA) donor templates, designed for homology directed …