Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

ABSTRACT Introduction Solute carriers (SLCs) represent the largest group of membrane
transporters in the human genome. They play a central role in controlling the …

The serotonin transporter (SERT) terminates serotonin signaling by using sodium and
chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of …

Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …

The neurotransmitter dopamine has central roles in mood, appetite, arousal and movement.
Despite its importance in brain physiology and function, and as a target for illicit and …

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is cleared from the synaptic cleft
by the sodium-and chloride-coupled GABA transporter GAT1. Inhibition of GAT1 prolongs …

Noradrenaline, also known as norepinephrine, has a wide range of activities and effects on
most brain cell types. Its reuptake from the synaptic cleft heavily relies on the noradrenaline …

The noradrenaline transporter (also known as norepinephrine transporter)(NET) has a
critical role in terminating noradrenergic transmission by utilizing sodium and chloride …

The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …

The dopamine transporter (DAT) is crucial for regulating dopamine signalling and is the
prime mediator for the rewarding and addictive effects of cocaine. As part of the …