[HTML][HTML] European Society of Gynecological Oncology Task Force for Fertility Preservation: clinical recommendations for fertility-sparing management in young …

A Rodolakis, I Biliatis, P Morice, N Reed… - International Journal of …, 2015 - Elsevier
Endometrial cancer (EC) in young women of reproductive age is a relatively rare diagnosis.
However, since in the modern era women delay their childbearing for a variety of social …

Combinational strategies of metformin and chemotherapy in cancers

HH Zhang, XL Guo - Cancer chemotherapy and pharmacology, 2016 - Springer
Chemotherapeutic regimens are the most common treatment to inhibit tumor growth, but
there is great variability in clinical responses of cancer patients; cancer cells often develop …

Efficacy of bariatric surgery in the treatment of women with obesity and polycystic ovary syndrome

L Hu, L Ma, X **a, T Ying, M Zhou, S Zou… - The Journal of …, 2022 - academic.oup.com
Context The comparative effectiveness of drugs and surgical therapy for women with obesity
and polycystic ovary syndrome (PCOS) has not been systematically compared. Objective …

High BMI and insulin resistance are risk factors for spontaneous abortion in patients with polycystic ovary syndrome undergoing assisted reproductive treatment: a …

YF Sun, J Zhang, YM Xu, ZY Cao, YZ Wang… - Frontiers in …, 2020 - frontiersin.org
Background The risk of spontaneous abortion in patients with polycystic ovary syndrome
(PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients …

TLR4-associated IRF-7 and NFκB signaling act as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium

M Hu, Y Zhang, X Li, P Cui… - The Journal of …, 2021 - academic.oup.com
Context Low-grade chronic inflammation is commonly seen in polycystic ovary syndrome
(PCOS) patients with elevated levels of inflammatory cytokines in the endometrium …

Metformin use and gynecological cancers: a novel treatment option emerging from drug repositioning

A Gadducci, N Biglia, R Tana, S Cosio… - Critical reviews in oncology …, 2016 - Elsevier
Metformin exerts antitumor effects mainly through AMP-activated protein kinase [AMPK]
activation and phosphatidylinositol 3-kinase [PI3K]-Akt-mammalian target of rapamycin …

[HTML][HTML] Diabetes mellitus and endometrial carcinoma: risk factors and etiological links

Y Wang, X Zeng, J Tan, Y Xu, C Yi - Medicine, 2022 - journals.lww.com
The presence of diabetes mellitus (DM) has a critical influence on the occurrence and
development of endometrial cancer (EC) and is associated with a poor prognosis. Patients …

Metformin ameliorates uterine defects in a rat model of polycystic ovary syndrome

Y Zhang, M Hu, F Meng, X Sun, H Xu, J Zhang, P Cui… - …, 2017 - thelancet.com
Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit
endocrine, metabolic, and reproductive abnormalities that are very similar to those observed …

Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

J Zhen, J Li, X Li, X Wang, Y **ao, Z Sun… - Journal of Biomedical …, 2021 - Springer
Objective Researchers have revealed the combined functions of long noncoding RNAs
(lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed …

Metformin as a therapeutic target in endometrial cancers

TY Lee, UE Martinez-Outschoorn, RJ Schilder… - Frontiers in …, 2018 - frontiersin.org
Endometrial cancer is the most common gynecologic malignancy in developed countries. Its
increasing incidence is thought to be related in part to the rise of metabolic syndrome, which …