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Nerve growth factor signaling and its contribution to pain
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …
and survival of sympathetic and sensory afferent neurons during development. A substantial …
The molecular basis of retinal ganglion cell death in glaucoma
M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …
results in visual field loss and irreversible blindness. A crucial element in the …
Neurotrophins as synaptic modulators
M Poo - Nature reviews neuroscience, 2001 - nature.com
The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …
neurons has been well described. More recent evidence indicates that neurotrophins may …
Gras** objects: the cortical mechanisms of visuomotor transformation
Gras** requires coding of the object's intrinsic properties (size and shape), and the
transformation of these properties into a pattern of distal (finger and wrist) movements …
transformation of these properties into a pattern of distal (finger and wrist) movements …
The cellular and molecular basis of peripheral nerve regeneration
SY Fu, T Gordon - Molecular neurobiology, 1997 - Springer
Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …
Nerve growth factor signaling, neuroprotection, and neural repair
▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …
The evolution of nerve growth factor inhibition in clinical medicine
BL Wise, MF Seidel, NE Lane - Nature Reviews Rheumatology, 2021 - nature.com
Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit
pain signals from the peripheral to the central nervous system and that exerts its effects on …
pain signals from the peripheral to the central nervous system and that exerts its effects on …
Neurotrophins and neuronal plasticity
H Thoenen - Science, 1995 - science.org
There is increasing evidence that neurotrophins (NTs) are involved in processes of neuronal
plasticity besides their well-established actions in regulating the survival, differentiation, and …
plasticity besides their well-established actions in regulating the survival, differentiation, and …
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
M Bibel, YA Barde - Genes & development, 2000 - genesdev.cshlp.org
Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …
of the nervous system. They are generated in remarkable numbers, particularly in higher …
Neurotrophin signaling through the p75 neurotrophin receptor
The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …
maintenance, survival, and death of the nervous system. The signal transducing systems …