Nerve growth factor signaling and its contribution to pain

PA Barker, P Mantyh, L Arendt-Nielsen… - Journal of pain …, 2020 - Taylor & Francis
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Neurotrophins as synaptic modulators

M Poo - Nature reviews neuroscience, 2001 - nature.com
The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

Gras** objects: the cortical mechanisms of visuomotor transformation

M Jeannerod, MA Arbib, G Rizzolatti, H Sakata - Trends in neurosciences, 1995 - Elsevier
Gras** requires coding of the object's intrinsic properties (size and shape), and the
transformation of these properties into a pattern of distal (finger and wrist) movements …

The cellular and molecular basis of peripheral nerve regeneration

SY Fu, T Gordon - Molecular neurobiology, 1997 - Springer
Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

Nerve growth factor signaling, neuroprotection, and neural repair

MV Sofroniew, CL Howe… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

The evolution of nerve growth factor inhibition in clinical medicine

BL Wise, MF Seidel, NE Lane - Nature Reviews Rheumatology, 2021 - nature.com
Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit
pain signals from the peripheral to the central nervous system and that exerts its effects on …

Neurotrophins and neuronal plasticity

H Thoenen - Science, 1995 - science.org
There is increasing evidence that neurotrophins (NTs) are involved in processes of neuronal
plasticity besides their well-established actions in regulating the survival, differentiation, and …

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system

M Bibel, YA Barde - Genes & development, 2000 - genesdev.cshlp.org
Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

Neurotrophin signaling through the p75 neurotrophin receptor

PP Roux, PA Barker - Progress in neurobiology, 2002 - Elsevier
The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …