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Modified nucleic acid aptamers: development, characterization, and biological applications
Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …
interactions. To improve the properties and performance of aptamers, modified nucleotides …
Chemical modifications for a next generation of nucleic acid aptamers
In the past three decades, in vitro systematic evolution of ligands by exponential enrichment
(SELEX) has yielded many aptamers for translational applications in both research and …
(SELEX) has yielded many aptamers for translational applications in both research and …
G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects
First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …
Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide
Ligand/protein molecular recognition involves a dynamic process, whereby both partners
require a degree of structural plasticity to regulate the binding/unbinding event. Here, we …
require a degree of structural plasticity to regulate the binding/unbinding event. Here, we …
[HTML][HTML] Overview of the therapeutic potential of aptamers targeting coagulation factors
Aptamers are single-stranded DNA or RNA sequences that bind target molecules with high
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …
Robust enzymatic production of DNA G-quadruplex, aptamer, DNAzyme, and other oligonucleotides: Applications for NMR
Single-stranded DNA (ssDNA) oligonucleotides are widely used in biological research,
therapeutics, biotechnology, and nanomachines. Large-scale enzymatic production of …
therapeutics, biotechnology, and nanomachines. Large-scale enzymatic production of …
[HTML][HTML] Design, synthesis and characterization of cyclic NU172 analogues: A biophysical and biological insight
NU172—a 26-mer oligonucleotide able to bind exosite I of human thrombin and inhibit its
activity—was the first aptamer to reach Phase II clinical studies as an anticoagulant in heart …
activity—was the first aptamer to reach Phase II clinical studies as an anticoagulant in heart …
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks
that continue to hinder their applications. Several strategies have been undertaken to …
that continue to hinder their applications. Several strategies have been undertaken to …
Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human α-thrombin
The long-range communication between the two exosites of human α-thrombin (thrombin)
tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an …
tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an …
Synthesis of piperidine nucleosides as conformationally restricted immucillin mimics
The de novo synthesis of piperidine nucleosides from our homologating agent 5, 6-dihydro-
1, 4-dithiin is herein reported. The structure and conformation of nucleosides were …
1, 4-dithiin is herein reported. The structure and conformation of nucleosides were …