Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Individuals with schizophrenia (SZ) exhibit cognitive performance below expected levels
based on familial cognitive aptitude. One such cognitive process, working memory (WM), is …

Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …

Dopamine is required for working memory, but how it modulates the large-scale cortex is
unknown. Here, we report that dopamine receptor density per neuron, measured by …

Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are
classified as major mental disorders and together account for the second-highest global …

The recent publications of the inter-areal connectomes for mouse, marmoset, and macaque
cortex have allowed deeper comparisons across rodent vs. primate cortical organization. In …

Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …

Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to
cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction …