The number of publicly available parasitic worm genome sequences has increased
dramatically in the past three years, and research interest in helminth functional genomics is …

The innate immune system is the first line of defense against pathogens, which is initiated by
the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …

Studies of model organisms have provided important insights into how natural genetic
differences shape trait variation. These discoveries are driven by the growing availability of …

Background Second-generation sequencing technologies are precipitating major shifts with
regards to what kinds of genomes are being sequenced and how they are annotated. While …

The RepeatMasker program is used for identifying repetitive elements in nucleotide
sequences for further detailed analyses. Users can run RepeatMasker remotely via a Web …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

Motivation: De novo repeat family identification is a challenging algorithmic problem of great
practical importance. As the number of genome sequencing projects increases, there is a …

MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including
humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal …

Toll-like receptors (TLRs) are transmembrane pattern recognition receptors that are best
known for their roles in innate immunity for the detection of and defense against microbial …

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by
multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to …