A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Self-driving laboratories for chemistry and materials science

G Tom, SP Schmid, SG Baird, Y Cao, K Darvish… - Chemical …, 2024 - ACS Publications
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

Autonomous chemical research with large language models

DA Boiko, R MacKnight, B Kline, G Gomes - Nature, 2023 - nature.com
Transformer-based large language models are making significant strides in various fields,
such as natural language processing,,,–, biology,, chemistry,–and computer programming …

Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs

G Bolla, B Sarma, AK Nangia - Chemical reviews, 2022 - ACS Publications
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

An outlook on microfluidics: the promise and the challenge

S Battat, DA Weitz, GM Whitesides - Lab on a Chip, 2022 - pubs.rsc.org
This perspective considers ways in which the field of microfluidics can increase its impact by
improving existing technologies and enabling new functionalities. We highlight applications …

A robotic platform for flow synthesis of organic compounds informed by AI planning

CW Coley, DA Thomas III, JAM Lummiss, JN Jaworski… - Science, 2019 - science.org
INTRODUCTION The ability to synthesize complex organic molecules is essential to the
discovery and manufacture of functional compounds, including small-molecule medicines …

Enzymes, In Vivo Biocatalysis, and Metabolic Engineering for Enabling a Circular Economy and Sustainability

P Intasian, K Prakinee, A Phintha, D Trisrivirat… - Chemical …, 2021 - ACS Publications
Since the industrial revolution, the rapid growth and development of global industries have
depended largely upon the utilization of coal-derived chemicals, and more recently, the …

The fundamentals behind the use of flow reactors in electrochemistry

T Noël, Y Cao, G Laudadio - Accounts of chemical research, 2019 - ACS Publications
Conspectus In the past decade, research into continuous-flow chemistry has gained a lot of
traction among researchers in both academia and industry. Especially, microreactors have …

[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …

Continuous Flow Upgrading of Selected C2–C6 Platform Chemicals Derived from Biomass

R Gerardy, DP Debecker, J Estager, P Luis… - Chemical …, 2020 - ACS Publications
The ever increasing industrial production of commodity and specialty chemicals inexorably
depletes the finite primary fossil resources available on Earth. The forecast of population …