Tailored biosensors for drug screening, efficacy assessment, and toxicity evaluation

Y Tao, L Chen, M Pan, F Zhu, D Zhu - ACS sensors, 2021 - ACS Publications
Biosensors have been flourishing in the field of drug discovery with pronounced
developments in the past few years. They facilitate the screening and discovery of innovative …

Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
Abscisic acid (ABA) is a hormone with a very long evolutionary history, dating back to the
earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely the …

[HTML][HTML] LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway

S Spinelli, G Begani, L Guida, M Magnone… - Molecular …, 2021 - Elsevier
Objective Abscisic acid (ABA) is a plant hormone also present and active in animals. In
mammals, ABA regulates blood glucose levels by stimulating insulin-independent glucose …

Abscisic acid, an evolutionary conserved hormone: Biosynthesis, therapeutic and diagnostic applications in mammals

A Gharib, C Marquez, M Meseguer-Beltran… - Biochemical …, 2024 - Elsevier
Abscisic acid (ABA), a phytohormone traditionally recognized for its role in plant stress
responses, has recently emerged as a significant player in mammalian defense …

New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists

N Scarano, F Di Palma, N Origlia, F Musumeci… - Pharmaceutics, 2023 - mdpi.com
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in
the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits …

Thermal measurements support a role of the ABA/LANCL1− 2 hormone/receptors system in thermogenesis

G Zocchi, F Fontanelli, S Spinelli, L Sturla… - Open …, 2024 - royalsocietypublishing.org
Abscisic acid (ABA) is a conserved 'stress hormone'in unicellular organisms, plants and
animals. In mammals, ABA and its receptors LANCL1 and LANCL2 stimulate insulin …

Phytohormone abscisic acid improves memory impairment and reduces neuroinflammation in 5xFAD mice by upregulation of LanC-like protein 2

SH Jeon, N Kim, YJ Ju, MS Gee, D Lee… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD), a type of dementia, is the most common neurodegenerative
disease in the elderly. Neuroinflammation caused by deposition of amyloid β (Aβ) is one of …

The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure

S Spinelli, V Cossu, M Passalacqua… - International Journal of …, 2023 - mdpi.com
The abscisic acid (ABA)/LANC-like protein 1/2 (LANCL1/2) hormone/receptor system
regulates glucose uptake and oxidation, mitochondrial respiration, and proton gradient …

Abscisic acid improves insulin action on glycemia in insulin-deficient mouse models of type 1 diabetes

M Magnone, S Spinelli, G Begani, L Guida, L Sturla… - Metabolites, 2022 - mdpi.com
Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia
regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism …

[HTML][HTML] Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism

S Spinelli, Z Humma, M Magnone, E Zocchi, L Sturla - Nutrients, 2024 - mdpi.com
Abscisic acid (ABA) is a hormone with a long evolutionary history, dating back to the earliest
living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants …