At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …

Current antiviral therapies, such as pegylated interferon-α and nucleos (t) ide analogues,
effectively improve the quality of life of patients with chronic hepatitis B. However, they can …

With more than 240 million people infected, hepatitis B virus (HBV) is a major health
concern. The inability to mimic the complexity of the liver using cell lines and regular primary …

Background & Aims In the presence of highly-potent antivirals, persistence of hepatitis B
virus (HBV) is most well-characterized by covalently-closed circular DNA (cccDNA) and total …

Background & Aims The chronicity of HBV (and resultant liver disease) is determined by
intrahepatic persistence of the HBV covalently closed circular DNA (cccDNA), an episomal …

Hepatitis B virus infection is the cause of liver diseases such as cirrhosis and liver cancer.
Understanding the host‐virus mechanisms that mediate virus pathogenesis can help design …

In-host models have been essential for understanding the dynamics of virus infection inside
an infected individual. When used together with biological data, they provide insight into …

Within-host models of COVID-19 infection dynamics enable the merits of different forms of
antiviral therapy to be assessed in individual patients. A stochastic agent-based model of …

Hepatitis B virus (HBV) is the major cause of virus-associated liver disease. Persistent HBV
infection is maintained by its episomal genome (covalently closed circular DNA, cccDNA) …

Hepatitis B virus (HBV) infection is a deadly liver disease. The main aim of this work is to
explore the role of cytoplasmic recycling of rcDNA-containing capsids in the hepatitis B virus …