Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania

T Lestinova, I Rohousova, M Sima… - PLoS neglected …, 2017 - journals.plos.org
Background Leishmaniases are parasitic diseases present worldwide that are transmitted to
the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine …

Saliva of hematophagous insects: a multifaceted toolkit

B Arcà, JMC Ribeiro - Current opinion in insect science, 2018 - Elsevier
Highlights•Salivary genes are highly divergent and evolve under strong selective
pressure.•Gene duplication played a major role in evolution of novel salivary …

A sand fly salivary protein acts as a neutrophil chemoattractant

AB Guimaraes-Costa, JP Shannon, I Waclawiak… - Nature …, 2021 - nature.com
Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect
protein that directly attracts mammalian innate cells such as neutrophils has not been …

Vaccinomics strategy to concoct a promising subunit vaccine for visceral leishmaniasis targeting sandfly and leishmania antigens

R Ojha, RK Pandey, VK Prajapati - International Journal of Biological …, 2020 - Elsevier
Visceral leishmaniasis (VL) has been declared as one of the most severely neglected
tropical diseases by the World Health Organization report 2017. Cumulative incidences of …

Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis

P Cecílio, B Pérez-Cabezas, L Fernández… - PLoS Neglected …, 2017 - journals.plos.org
The notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-
Leishmania immunity, supports vaccination as a potentially effective approach to prevent …

An overview of the sand fly salivary proteins in vaccine development against leishmaniases

S Fayaz, F Bahrami, P Parvizi… - Iranian Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Leishmaniases are a group of vector-borne parasitic diseases transmitted through the
infected sand flies. Leishmania parasites are inoculated into the host skin along with sand fly …

Functional and structural similarities of D7 proteins in the independently-evolved salivary secretions of sand flies and mosquitoes

W Jablonka, IH Kim, PH Alvarenga, JG Valenzuela… - Scientific reports, 2019 - nature.com
The habit of blood feeding evolved independently in many insect orders of families. Sand
flies and mosquitoes belong to separate lineages of blood-feeding Diptera and are thus …

An overview of D7 protein structure and physiological roles in blood-feeding nematocera

PH Alvarenga, JF Andersen - Biology, 2022 - mdpi.com
Simple Summary Vectors are organisms that can transmit infectious pathogens from a host
(human or animal) to another. Many vectors (including mosquitoes, sand flies and ticks) …

Detection of Wolbachia and Leishmania DNA in sand flies (Diptera: Psychodidae, Phlebotominae) from a focus of cutaneous leishmaniasis in Tabasco, Mexico

YN Lozano-Sardaneta, E Jacobo-Olvera… - Parasitology …, 2022 - Springer
Phlebotomine sand flies are the main vectors of Leishmania genus species worldwide;
therefore, the detection of some reproductive parasites, such as Wolbachia, has been …

RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions

LH Patino, JD Ramírez - Infection, Genetics and Evolution, 2017 - Elsevier
The kinetoplastids include a large number of parasites responsible for serious diseases in
humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several …