Protein arginine methylation: from enigmatic functions to therapeutic targeting
Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
Clinical development of metabolic inhibitors for oncology
Metabolic inhibitors have been used in oncology for decades, dating back to antimetabolites
developed in the 1940s. In the past 25 years, there has been increased recognition of …
developed in the 1940s. In the past 25 years, there has been increased recognition of …
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …
RNA-based diagnostic markers discovery and therapeutic targets development in cancer
H Wang, Q Meng, J Qian, M Li, C Gu, Y Yang - Pharmacology & …, 2022 - Elsevier
The present review aimed to outline different types of RNAs in cancer diagnostics and
treatment, and to provide novel insights into their clinical applications. RNAs, including …
treatment, and to provide novel insights into their clinical applications. RNAs, including …
RNA methyltransferase METTL16: Targets and function
Abstract The N6‐methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging
player in the RNA modification landscape of the human cell. Originally thought to be a …
player in the RNA modification landscape of the human cell. Originally thought to be a …
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
Interplay between EBV infection and acquired genetic alterations during nasopharyngeal
carcinoma (NPC) development remains vague. Here we report a comprehensive genomic …
carcinoma (NPC) development remains vague. Here we report a comprehensive genomic …
Overview of methionine adenosyltransferase 2A (MAT2A) as an anticancer target: structure, function, and inhibitors
C Li, G Gui, L Zhang, A Qin, C Zhou… - Journal of Medicinal …, 2022 - ACS Publications
Methionine adenosyltransferase 2A (MAT2A) is a rate-limiting enzyme in the methionine
cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine …
cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine …