Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-
translationally modified peptide (RiPP) natural products characterized by their slip knot-like …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …

Advances in genome sequencing and bioinformatics methods have identified a myriad of
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …

We report the development of a novel synthetic approach for the highly strained atrop‐Tyr C‐
6‐to‐Trp N‐1′ linkage, which can be executed on a decagram scale using a modular …

The structure of the sidechain crosslinked Tyr‐Leu‐Trp peptide produced by the biarylitide
crosslinking cytochrome P450Blt from Micromonospora sp. MW‐13 has been reanalysed by …

Peptide cyclization is a defining feature of many bioactive molecules, particularly in the
ribosomally synthesized and post-translationally modified peptide (RiPP) family of natural …

Novel discoveries in natural product biosynthesis reveal hidden bioactive compounds and
expand our knowledge in enzymology. Ribosomally synthesized and post-translationally …

Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) defined by a macrolactam linkage between the N-terminus and the side …

Isoprenoid modifications of proteins and peptides serve fundamental biological functions
and are of therapeutic interest. While C 15 (farnesyl) and C 20 (geranylgeranyl) moieties are …