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Ageing, age-related diseases and oxidative stress: What to do next?
Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …
Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …
progressive autoimmune disease affecting many people worldwide. While patients show …
New insights into the immunopathogenesis of systemic lupus erythematosus
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …
Pathogenesis of respiratory viral and fungal coinfections
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for develo** invasive fungal infections. Influenza virus is one of the most …
“at risk” groups for develo** invasive fungal infections. Influenza virus is one of the most …
[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …
Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different MO
Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …
[HTML][HTML] Unlocking the power of NOX2: A comprehensive review on its role in immune regulation
Reactive oxygen species (ROS) are a family of highly reactive molecules with numerous,
often pleiotropic functions within the cell and the organism. Due to their potential to destroy …
often pleiotropic functions within the cell and the organism. Due to their potential to destroy …
From flies to men: ROS and the NADPH oxidase in phagocytes
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …
Immunometabolism in early and late stages of rheumatoid arthritis
One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …