Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …

Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …

Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …

Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …

Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial
with exciting potential for tissue engineering and regenerative medicine applications. Clay …

Nanomaterials have demonstrated a wide range of applications and recently, novel
biomedical studies are devoted to improving the functionality and effectivity of traditional and …

Mitochondrial dysfunction in tissue‐specific mesenchymal stem cells (MSCs) plays a critical
role in cell fate and the morbidity of chronic inflammation‐associated bone diseases, such …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …