Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Leptin-aldosterone-neprilysin axis: Identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity

M Packer - Circulation, 2018 - ahajournals.org
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

[HTML][HTML] Intestinal microbiota determine severity of myocardial infarction in rats

VY Lam, J Su, S Koprowski, A Hsu… - The FASEB …, 2012 - pmc.ncbi.nlm.nih.gov
Signals from the intestinal microbiota are important for normal host physiology; alteration of
the microbiota (dysbiosis) is associated with multiple disease states. We determined the …

Epicardial Adipose Tissue–Derived Leptin Promotes Myocardial Injury in Metabolic Syndrome Rats Through PKC/NADPH Oxidase/ROS Pathway

H Chen, L Liu, M Li, D Zhu, G Tian - Journal of the American Heart …, 2023 - ahajournals.org
Background The epicardial adipose tissue (EAT) of metabolic syndrome (MetS) is
abnormally accumulated with dysfunctional secretion of adipokines, closely relating to …

Adipokines and the cardiovascular system: mechanisms mediating health and disease

JM Northcott, A Yeganeh, CG Taylor… - Canadian journal of …, 2012 - cdnsciencepub.com
This review focuses on the role of adipokines in the maintenance of a healthy cardiovascular
system, and the mechanisms by which these factors mediate the development of …

Germinated brown rice ameliorates obesity in high-fat diet induced obese rats

SM Lim, YM Goh, N Mohtarrudin, SP Loh - BMC complementary and …, 2016 - Springer
Background Germinated brown rice (GBR) is a novel functional food that is high in fiber and
bioactive compounds with health-promoting properties. This study aims to evaluate anti …

Involvement of L‐type calcium channel and SERCA2a in myocardial dysfunction induced by obesity

AS Leopoldo, AP Lima‐Leopoldo… - Journal of Cellular …, 2011 - Wiley Online Library
Obesity has been shown to impair myocardial performance. Nevertheless, the mechanisms
underlying the participation of calcium (Ca2+) handling on cardiac dysfunction in obesity …

Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling

AP Lima-Leopoldo, AS Leopoldo… - Journal of applied …, 2014 - journals.physiology.org
Few studies have evaluated the relationship between the duration of obesity, cardiac
function, and the proteins involved in myocardial calcium (Ca2+) handling. We hypothesized …

Cardiac Dysfunction Induced by Obesity Is Not Related to β-Adrenergic System Impairment at the Receptor-Signalling Pathway

AJT Ferron, BB Jacobsen, PG Sant'Ana… - PLoS …, 2015 - journals.plos.org
Obesity has been shown to impair myocardial performance. Some factors have been
suggested as responsible for possible cardiac abnormalities in models of obesity, among …

[HTML][HTML] Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy

MR Kandadi, E Panzhinskiy, ND Roe, S Nair… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Obesity-induced cardiomyopathy may be mediated by alterations in multiple signaling
cascades involved in glucose and lipid metabolism. Protein tyrosine phosphatase-1B …