Progress and prospects on vaccine development against monkeypox infection

MJ Saadh, T Ghadimkhani, N Soltani… - Microbial …, 2023 - Elsevier
The monkeypox virus (MPOX) is an uncommon zoonotic illness brought on by an
orthopoxvirus (OPXV). MPOX can occur with symptoms similar to smallpox. Since April 25 …

Monkeypox: A comprehensive review on mutation, transmission, pathophysiology, and therapeutics

S Dutta, R Ghosh, I Dasgupta, P Sikdar, P Santra… - International …, 2025 - Elsevier
Monkeypox virus (MPXV) is the causative agent of the monkeypox (Mpox) disease, belongs
to the Orthopoxvirus genus of the Poxviridae family. Due to the recent re-emergence of Mpox …

Monkeypox: a viral zoonotic disease of rising global concern

S Anil, B Joseph, M Thomas, VK Sweety… - Infectious Diseases & …, 2024 - mednexus.org
Monkeypox (mpox) is a rare viral zoonotic disease, endemic to Central and West Africa,
caused by the monkeypox virus, an orthopoxvirus similar to the variola virus (smallpox) …

Development of a Multi-epitope Universal mRNA vaccine candidate for Monkeypox, Smallpox, and Vaccinia viruses: design and in Silico analyses

N Rcheulishvili, J Mao, D Papukashvili, S Feng, C Liu… - Viruses, 2023 - mdpi.com
Notwithstanding the presence of a smallpox vaccine that is effective against monkeypox
(mpox), develo** a universal vaccine candidate against monkeypox virus (MPXV) is …

Design, evaluation, and immune simulation of potentially universal multi-epitope mpox vaccine candidate: focus on DNA vaccine

N Rcheulishvili, J Mao, D Papukashvili… - Frontiers in …, 2023 - frontiersin.org
Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox
symptoms are similar to smallpox with less severity and lower mortality. As yet mpox virus is …

Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice

J Zhou, T Ye, Y Yang, E Li, K Zhang, Y Wang, S Chen… - Molecular Therapy, 2024 - cell.com
Since the outbreak of monkeypox (mpox) in 2022, widespread concern has been placed on
imposing an urgent demand for specific vaccines that offer safer and more effective …

Mpox: Global epidemic situation and countermeasures

W Hou, N Wu, Y Liu, Y Tang, Q Quan, Y Luo, C ** - Virulence, 2025 - Taylor & Francis
Mpox, is a zoonotic disease caused by the monkeypox virus and is primarily endemic to
Africa. As countries gradually stop smallpox vaccination, resistance to the smallpox virus is …

Intriguing insight into unanswered questions about Mpox: exploring health policy implications and considerations

E Manirambona, SH Khan, A Siddiq, K Albakri… - Health Research Policy …, 2024 - Springer
Abstract The 2022 multi-country Monkeypox (Mpox) outbreak has added concerns to
scientific research. However, unanswered questions about the disease remain. These …

Human mpox: global trends, molecular epidemiology and options for vaccination

L Subissi, P Stefanelli, G Rezza - Pathogens and Global Health, 2024 - Taylor & Francis
The eradication of smallpox and the cessation of vaccination have led to the growth of the
susceptible human population to poxviruses. This has led to the increasing detection of …

Chemical cross‐linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual‐antigen subunit vaccine

L Chen, C Shang, Z Wang, M Zheng, C Zhang… - MedComm, 2025 - Wiley Online Library
Antigen uptake, processing, and presentation are crucial for the immune responses of
protein‐based vaccines. Herein, we introduced a reversible chemical cross‐linking strategy …