Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
Mechanisms and consequences of macromolecular phase separation
Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …
Proteins containing expanded polyglutamine tracts and neurodegenerative disease
Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments
The 17-amino-acid N-terminal segment (httNT) that leads into the polyglutamine (polyQ)
segment in the Huntington's disease protein huntingtin (htt) dramatically increases …
segment in the Huntington's disease protein huntingtin (htt) dramatically increases …
Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence
R Wetzel - Journal of molecular biology, 2012 - Elsevier
Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …
number of proteins, and their repeat expansion is associated with a number of genetic …
Nanoparticle-guided brain drug delivery: Expanding the therapeutic approach to neurodegenerative diseases
Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …
disorders featured by progressive impairment of motor and/or cognitive functions, often …
Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a
polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) …
polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) …
Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation
E Monsellier, V Redeker, G Ruiz-Arlandis… - Journal of Biological …, 2015 - ASBMB
The aggregation of polyglutamine (polyQ)-containing proteins is at the origin of nine
neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ …
neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ …
Unraveling the Puzzle of Therapeutic Peptides: A Promising Frontier in Huntington's Disease Treatment
S Ahamad, N Bano, S Khan, MK Hussain… - Journal of Medicinal …, 2024 - ACS Publications
Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by a
mutation in the huntingtin (HTT) gene, resulting in the production of a mutant huntingtin …
mutation in the huntingtin (HTT) gene, resulting in the production of a mutant huntingtin …
Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance
CL Hoop, HK Lin, K Kar, Z Hou, MA Poirier… - Biochemistry, 2014 - ACS Publications
In Huntington's disease, expansion of a polyglutamine (polyQ) domain in the huntingtin (htt)
protein leads to misfolding and aggregation. There is much interest in the molecular features …
protein leads to misfolding and aggregation. There is much interest in the molecular features …