[HTML][HTML] Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers

CH Lin, CH Chen, ZC Lin, JY Fang - Journal of food and drug analysis, 2017 - Elsevier
Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper the oral delivery of
many labile drugs. The GI epithelium also contributes to poor permeability for numerous …

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

B Zeng, A Wei, Q Zhou, M Yuan, K Lei… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in
China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and …

Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality?

CA Houghton, RG Fassett… - Oxidative medicine and …, 2016 - Wiley Online Library
The recognition that food‐derived nonnutrient molecules can modulate gene expression to
influence intracellular molecular mechanisms has seen the emergence of the fields of …

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

MT Islam, ES Ali, SJ Uddin, MA Islam, S Shaw, IN Khan… - Cancer letters, 2018 - Elsevier
The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been
proven to possess several important protective biological activities, including antioxidant …

Anticancer potential of andrographolide from Andrographis paniculata (Burm. f.) Nees and its mechanisms of action

Z Malik, R Parveen, B Parveen, S Zahiruddin… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Synthetic drugs used for cancer treatment have side
effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and …

Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

CC Yen, YC Chen, MT Wu, CC Wang… - International journal of …, 2018 - Taylor & Francis
Background Andrographolide (AG), a compound with low water solubility, possesses
various pharmacological activities, particularly anti-inflammatory activity. However, its low …

Opportunities and challenges in managing antibiotic resistance in bacteria using plant secondary metabolites

B Kongkham, D Prabakaran, H Puttaswamy - Fitoterapia, 2020 - Elsevier
Abstract Development of antibiotic resistance (ABR) in bacteria and its multidimensional
spread is an emerging global threat that needs immediate attention. Extensive antibiotics …

A validated LC–MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata …

P Songvut, N Pholphana, T Suriyo, N Rangkadilok… - Scientific Reports, 2023 - nature.com
Andrographis paniculata, a medicinal plant in Thailand national list of essential medicines,
has been proposed for treatment of patients with mild to moderate coronavirus disease …

[HTML][HTML] Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update

S Mehta, AK Sharma, RK Singh - Phytomedicine Plus, 2021 - Elsevier
Abstract Background Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a
herbaceous plant used in traditional medicines for the treatment of various ailments …

Andrographis paniculata (Burm. F.) Wall. Ex Nees, Andrographolide, and Andrographolide Analogues as SARS-CoV-2 Antivirals? A Rapid Review

XY Lim, JSW Chan, TYC Tan, BP Teh… - Natural Product …, 2021 - journals.sagepub.com
Drug repurposing is commonly employed in the search for potential therapeutic agents.
Andrographis paniculata, a medicinal plant commonly used for symptomatic relief of the …