Physiological and pathological roles of lipogenesis
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
Role of insulin resistance in MAFLD
Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …
Reprogramming tumour-associated macrophages to outcompete cancer cells
In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
Metabolic codependencies in the tumor microenvironment
Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …
Mechanism and medical implications of mammalian autophagy
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
Z Shen, M **ang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
Insulin action and resistance in obesity and type 2 diabetes
MP Czech - Nature medicine, 2017 - nature.com
Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes
The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …