The gut microbiome's role in the development, maintenance, and outcomes of sepsis

MW Adelman, MH Woodworth, C Langelier, LM Busch… - Critical care, 2020 - Springer
The gut microbiome regulates a number of homeostatic mechanisms in the healthy host
including immune function and gut barrier protection. Loss of normal gut microbial structure …

Pulmonary infections complicating ARDS

CE Luyt, L Bouadma, AC Morris, JA Dhanani… - Intensive care …, 2020 - Springer
Pulmonary infection is one of the main complications occurring in patients suffering from
acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of …

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections

J Schlechte, AZ Zucoloto, I Yu, CJ Doig, MJ Dunbar… - Nature Medicine, 2023 - nature.com
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …

[HTML][HTML] Antibiotic resistance in the commensal human gut microbiota

LE Lamberte, W van Schaik - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•The human gut microbiota serves as a reservoir of antibiotic resistance
genes.•DNA sequencing and culture techniques are used to characterise the gut …

Extensive microbial diversity within the chicken gut microbiome revealed by metagenomics and culture

R Gilroy, A Ravi, M Getino, I Pursley, DL Horton… - PeerJ, 2021 - peerj.com
Background: The chicken is the most abundant food animal in the world. However, despite
its importance, the chicken gut microbiome remains largely undefined. Here, we exploit …

The microbial ecology of Escherichia coli in the vertebrate gut

E Foster-Nyarko, MJ Pallen - FEMS microbiology reviews, 2022 - academic.oup.com
Escherichia coli has a rich history as biology's 'rock star', driving advances across many
fields. In the wild, E. coli resides innocuously in the gut of humans and animals but is also a …

Antimicrobial-associated harm in critical care: a narrative review

N Arulkumaran, M Routledge, S Schlebusch… - Intensive care …, 2020 - Springer
The belief that, for the individual patient, the benefit of prompt and continued use of
antimicrobials outweighs any potential harm is a significant barrier to improved stewardship …

Metagenome-assembled genome binning methods with short reads disproportionately fail for plasmids and genomic islands

F Maguire, B Jia, KL Gray, WYV Lau… - Microbial …, 2020 - microbiologyresearch.org
Metagenomic methods enable the simultaneous characterization of microbial communities
without time-consuming and bias-inducing culturing. Metagenome-assembled genome …

[HTML][HTML] Vancomycin-resistant Enterococcus faecium and the emergence of new sequence types associated with hospital infection

RF O'Toole, KWC Leong, V Cumming… - Research in …, 2023 - Elsevier
Enterococcus faecium is a major species in infections by vancomycin-resistant enterococci
(VRE). New variants of the pathogen have emerged and become dominant in healthcare …

The multifaceted lifestyle of enterococci: genetic diversity, ecology and risks for public health

V Cattoir - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Enterococci have become major human MDR nosocomial pathogens.•They are
found ubiquitously in non-human habitats (animals and the environment).•The main threat …