Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its
role in bone remodeling and orthodontic tooth movement are discussed based on available …

Biomineralization of enamel, dentin, and bone involves the deposition of apatite mineral
crystals within an organic matrix. Bone and teeth are classic examples of biomaterials with …

Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant
importance since most of the outstanding properties of the bone are due to matrix …

Highlights•Osteocytes regulate bone formation through a number of interacting signalling
pathways.•Osteocytes regulate bone resorption through controlling osteoclast activity and …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Several studies have shown that the dentin‐resin interface is unstable due to poor infiltration
of resin monomers into the demineralized dentin matrix. This phenomenon is related to the …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

Odontoblasts are specialized cells that produce dentin and exhibit unique morphological
characteristics; ie, they extend cytoplasmic processes into dentinal tubules. While …