Folic acid antimetabolites (antifolates): a brief review on synthetic strategies and application opportunities
Antimetabolites of folic acid represent a large group of drugs and drug candidates, including
those for cancer chemotherapy. In this current review, the most common methods and …
those for cancer chemotherapy. In this current review, the most common methods and …
Weapons and strategies against COVID-19: A perspective
Currently, there are no approved treatments for the fatal infectious coronavirus disease. The
process of identifying new applications for approved pharmaceuticals is called drug …
process of identifying new applications for approved pharmaceuticals is called drug …
Computational bioprospecting guggulsterone against ADP ribose phosphatase of SARS-CoV-2
Coronavirus Disease-2019 (COVID-19) is a highly contagious disease caused by Severe
Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization …
Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization …
In silico bioprospecting of taraxerol as a main protease inhibitor of SARS-CoV-2 to develop therapy against COVID-19
COVID-19 was caused by a novel coronavirus known as SARS-CoV-2. The COVID-19
disease outbreak has been avowed as a global pandemic by the World Health Organization …
disease outbreak has been avowed as a global pandemic by the World Health Organization …
[HTML][HTML] Design of novel anti-cancer agents targeting COX-2 inhibitors based on computational studies
The overexpression of cyclooxygenase-2 (COX-2) was clearly associated with
carcinogenesis, and COX-2 as a possible target has long been exploited for cancer therapy …
carcinogenesis, and COX-2 as a possible target has long been exploited for cancer therapy …
Computational design, synthesis, and pharmacological evaluation of naproxen-guaiacol chimera for gastro-sparing anti-inflammatory response by selective COX2 …
The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its
antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore …
antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore …
Design of novel anti-cancer drugs targeting TRKs inhibitors based 3D QSAR, molecular docking and molecular dynamics simulation
Tropomyosin receptor kinase (TRK) enzymes are responsible for different types of tumors
caused by neurotrophic tyrosine receptor kinase gene fusion and have been identified as an …
caused by neurotrophic tyrosine receptor kinase gene fusion and have been identified as an …
In silico insights into the design of novel NR2B-selective NMDA receptor antagonists: QSAR modeling, ADME-toxicity predictions, molecular docking, and molecular …
Based on a structural family of thirty-two NR2B-selective N-Methyl-D-Aspartate receptor
(NMDAR) antagonists, two phenylpiperazine derivatives labeled C37 and C39 were …
(NMDAR) antagonists, two phenylpiperazine derivatives labeled C37 and C39 were …
Agarwood oil nanoemulsion counteracts LPS-induced inflammation and oxidative stress in RAW264. 7 mouse macrophages
Purpose Oxidative stress and inflammation are key pathophysiological features of chronic
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …
QSAR, molecular docking, and molecular dynamics simulation–based design of novel anti-cancer drugs targeting thioredoxin reductase enzyme
Thioredoxin reductase (TrxR) plays an important role in the reduction of thioredoxin (Trx),
which is found to be involved in the upregulation of a diversity of tumors, including those …
which is found to be involved in the upregulation of a diversity of tumors, including those …