Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …

When used appropriately, a confocal fluorescence microscope is an excellent tool for
making quantitative measurements in cells and tissues. The confocal microscope's ability to …

INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

A few scientists who have been burned by bad experiences with antibodies have begun to
speak up. Rimm's disappointment set him on a crusade to educate others by writing reviews …

Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as
part of the diagnostic workup for the majority of solid tissue malignancies. Existing IHC …

We convened an ad hoc International Working Group for Antibody Validation in order to
formulate the best approaches for validating antibodies used in common research …

Reproducibility: Standardize antibodies used in research | Nature Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Aptamers have been identified against various targets as a type of chemical or nucleic acid
ligand by systematic evolution of ligands by exponential enrichment (SELEX) with high …

Objectives The interaction between the immune system and tumor cells is an important
feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) …

Multiplexed antibody-based imaging enables the detailed characterization of molecular and
cellular organization in tissues. Advances in the field now allow high-parameter data …