Broadly neutralizing antiviral antibodies

D Corti, A Lanzavecchia - Annual review of immunology, 2013 - annualreviews.org
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …

The status of vaccine development against the human cytomegalovirus

SA Plotkin, D Wang, A Oualim… - The Journal of …, 2020 - academic.oup.com
Numerous candidate vaccines against cytomegalovirus (CMV) infection and disease are in
development. Whereas the previous article provides background and opinions about the …

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

MR Sponholtz, PO Byrne, AG Lee… - Proceedings of the …, 2024 - pnas.org
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …

[HTML][HTML] Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

S John, O Yuzhakov, A Woods, J Deterling, K Hassett… - Vaccine, 2018 - Elsevier
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry

Y Wu, A Prager, S Boos, M Resch, I Brizic… - PLoS …, 2017 - journals.plos.org
Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …

HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions

CS Nelson, T Huffman, JA Jenks… - Proceedings of the …, 2018 - National Acad Sciences
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide,
frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent …

Crystal structure of the human cytomegalovirus glycoprotein B

HG Burke, EE Heldwein - PLoS pathogens, 2015 - journals.plos.org
Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that
establishes lifelong latent infections and caused disease in persons with compromised …

[HTML][HTML] Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

M Zehner, M Alt, A Ashurov, JA Goldsmith, R Spies… - Immunity, 2023 - cell.com
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and
immunocompromised individuals. Currently, no vaccines are approved, and treatment …

Cytomegalovirus vaccines: current status and future prospects

KM Anderholm, CJ Bierle, MR Schleiss - Drugs, 2016 - Springer
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent
neurological injury in newborns, and vaccine development is accordingly a major public …

Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection

D Lilleri, A Kabanova, MG Revello, E Percivalle… - PloS one, 2013 - journals.plos.org
Primary human cytomegalovirus (HCMV) infections during pregnancy are associated with a
high risk of virus transmission to the fetus. To identify correlates of intrauterine HCMV …