Broadly neutralizing antiviral antibodies
D Corti, A Lanzavecchia - Annual review of immunology, 2013 - annualreviews.org
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …
immune response. The widely held view has been that the great variability of viral …
The status of vaccine development against the human cytomegalovirus
SA Plotkin, D Wang, A Oualim… - The Journal of …, 2020 - academic.oup.com
Numerous candidate vaccines against cytomegalovirus (CMV) infection and disease are in
development. Whereas the previous article provides background and opinions about the …
development. Whereas the previous article provides background and opinions about the …
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation
MR Sponholtz, PO Byrne, AG Lee… - Proceedings of the …, 2024 - pnas.org
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …
[HTML][HTML] Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …
reducing CMV disease in transplant patients remains a high priority as no approved …
Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …
HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide,
frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent …
frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent …
Crystal structure of the human cytomegalovirus glycoprotein B
HG Burke, EE Heldwein - PLoS pathogens, 2015 - journals.plos.org
Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that
establishes lifelong latent infections and caused disease in persons with compromised …
establishes lifelong latent infections and caused disease in persons with compromised …
[HTML][HTML] Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and
immunocompromised individuals. Currently, no vaccines are approved, and treatment …
immunocompromised individuals. Currently, no vaccines are approved, and treatment …
Cytomegalovirus vaccines: current status and future prospects
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent
neurological injury in newborns, and vaccine development is accordingly a major public …
neurological injury in newborns, and vaccine development is accordingly a major public …
Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection
D Lilleri, A Kabanova, MG Revello, E Percivalle… - PloS one, 2013 - journals.plos.org
Primary human cytomegalovirus (HCMV) infections during pregnancy are associated with a
high risk of virus transmission to the fetus. To identify correlates of intrauterine HCMV …
high risk of virus transmission to the fetus. To identify correlates of intrauterine HCMV …