Simple Summary Cancer remains a major killer of the human population. Current cancer
diagnostic and therapeutic methods are associated with shortcomings of limited targetability …

Proto-oncogene tyrosine-protein kinase Src, also known as c-Src, belongs to the family of
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …

Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis,
serving pro-survival functions in malignant transformation and tumorigenesis. However, the …

Long non-coding RNAs (lncRNAs) have been revealed to harbor open reading frames
(ORFs) that can be translated into small peptides. The peptides may participate in the …

Precision oncology has revolutionized the treatment of ALK-positive lung cancer with
targeted therapies. However, an unmet clinical need still to address is the treatment of …

Using dasatinib linked to E3 ligase ligands, we identified a potent and selective dual Csk/c-
Src PROTAC degrader. We then replaced dasatinib, the c-Src-directed ligand, with a …

Kaempferol (Kae) is a natural flavonoid that has multiple biological activities, such as anti‐
inflammatory and antitumor activities. However, few studies have been reported on …

Host-acting compounds are emerging as potential alternatives to combating antibiotic
resistance. Here, we show that bosutinib, an FDA-approved chemotherapeutic for treating …

Chemotherapy resistance and treatment failure hinder clinical cancer treatment. Src, the first
mammalian proto‐oncogene to be discovered, is a valuable anti‐cancer therapeutic target …

Gallbladder cancer (GBC) is a highly aggressive malignancy, which poses significant
challenges for timely diagnosis, resulting in a dismal prognosis. Chemotherapy serves as a …