Late-stage C–H functionalization of azines

CM Josephitis, HMH Nguyen, A McNally - Chemical reviews, 2023 - ACS Publications
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Skeletal editing of pyridines through atom-pair swap from CN to CC

Q Cheng, D Bhattacharya, M Haring, H Cao… - Nature Chemistry, 2024 - nature.com
Skeletal editing is a straightforward synthetic strategy for precise substitution or
rearrangement of atoms in core ring structures of complex molecules; it enables quick …

Photoredox-catalyzed C–H functionalization reactions

N Holmberg-Douglas, DA Nicewicz - Chemical reviews, 2021 - ACS Publications
The fields of C–H functionalization and photoredox catalysis have garnered enormous
interest and utility in the past several decades. Many different scientific disciplines have …

Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines

H Cao, Q Cheng, A Studer - Science, 2022 - science.org
Carbon-hydrogen (C− H) functionalization of pyridines is a powerful tool for the rapid
construction and derivatization of many agrochemicals, pharmaceuticals, and materials …

Site-selective C–H functionalization to access the arene backbone of indoles and quinolines

B Prabagar, Y Yang, Z Shi - Chemical Society Reviews, 2021 - pubs.rsc.org
The site-selective C–H bond functionalization of heteroarenes can eventually provide
chemists with great techniques for editing and building complex molecular scaffolds. During …

Halogenation of the 3-position of pyridines through Zincke imine intermediates

BT Boyle, JN Levy, L de Lescure, RS Paton, A McNally - Science, 2022 - science.org
Pyridine halogenation reactions are crucial for obtaining the vast array of derivatives
required for drug and agrochemical development. However, despite more than a century of …

[HTML][HTML] A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

C Sambiagio, D Schönbauer, R Blieck… - Chemical Society …, 2018 - pubs.rsc.org
The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …

Organophotoelectrocatalytic C (sp 2)–H alkylation of heteroarenes with unactivated C (sp 3)–H compounds

Q Wan, XD Wu, ZW Hou, Y Ma, L Wang - Chemical Communications, 2024 - pubs.rsc.org
An organophotoelectrocatalytic method for the C (sp2)–H alkylation of heteroarenes with
unactivated C (sp3)–H compounds through dehydrogenation cross-coupling has been …

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

S Rej, A Das, N Chatani - Coordination Chemistry Reviews, 2021 - Elsevier
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …