Chemotherapy-induced cognitive impairment and hippocampal neurogenesis: a review of physiological mechanisms and interventions

MJ Sekeres, M Bradley-Garcia… - International journal of …, 2021‏ - mdpi.com
A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …

Chemobrain: A review on mechanistic insight, targets and treatments

V Rao, R Bhushan, P Kumari, SP Cheruku… - Advances in cancer …, 2022‏ - Elsevier
Chemo-brain refers to the thinking and memory problems that occur in cancer patients
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …

Nose-to-brain delivery of chrysin transfersomal and composite vesicles in doxorubicin-induced cognitive impairment in rats: Insights on formulation, oxidative stress …

SS Ibrahim, OGA Elseoud, MH Mohamedy, MM Amer… - …, 2021‏ - Elsevier
Many cancer survivors suffer from chemotherapy-induced cognitive impairment known as
'Chemobrain'. Doxorubicin-topoisomerase II inhibitor-is widely used in breast cancer …

Neuroprotective potential of berberine against doxorubicin-induced toxicity in rat's brain

G Ibrahim Fouad, KA Ahmed - Neurochemical Research, 2021‏ - Springer
Chemotherapy-associated neurotoxicity is one of the principal side-effects for doxorubicin
(DOX)-treated cancer patients. Despite its poor-penetration across the blood–brain barrier …

Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis

AE El-Sahar, AA Rastanawi, MF El-Yamany, MA Saad - Life Sciences, 2020‏ - Elsevier
Aims Huntington's disease is a rare neurodegenerative disorder which is associated with
defected glucose metabolism with consequent behavioral disturbance including memory …

[HTML][HTML] Cancer Chemotherapy Related Cognitive Impairment and the Impact of the Alzheimer's Disease Risk Factor APOE

HR Fernandez, A Varma, SA Flowers, GW Rebeck - Cancers, 2020‏ - mdpi.com
Simple Summary Research into the causes and potential treatments for cancer-related
cognitive impairment has increased greatly over the past several years. Advances have …

C-phycocyanin mitigates cognitive impairment in doxorubicin-induced chemobrain: impact on neuroinflammation, oxidative stress, and brain mitochondrial and …

C Wang, Y Zhao, L Wang, S Pan, Y Liu, S Li… - Neurochemical …, 2021‏ - Springer
Chemotherapy-induced cognitive impairment (CICI) is a common detrimental effect of
cancer treatment, occurring in up to 75% of cancer patients. The widely utilized …

Resveratrol improves paclitaxel-induced cognitive impairment in mice by activating SIRT1/PGC-1α pathway to regulate neuronal state and microglia cell polarization

X Liu, M Tang, TY He, S Zhao, HZ Li, Z Li… - Drug Design …, 2023‏ - Taylor & Francis
Objective This study aimed to investigate the effect of resveratrol (Res) on paclitaxel (PTX)-
induced cognitive impairment and elucidate the underlying molecular mechanisms. Methods …

[HTML][HTML] Quetiapine moderates doxorubicin-induced cognitive deficits: Influence of oxidative stress, neuroinflammation, and cellular apoptosis

V Mani, BS Alshammeri - International Journal of Molecular Sciences, 2023‏ - mdpi.com
Chemotherapy is considered a major choice in cancer treatment. Unfortunately, several
cognitive deficiencies and psychiatric complications have been reported in patients with …

[HTML][HTML] The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype

T Demby, PS Gross, J Mandelblatt, JK Huang… - Experimental …, 2024‏ - Elsevier
Many cancer patients experience serious cognitive problems related to their treatment,
which can greatly affect their quality of life. The molecular mechanisms of this cancer …