Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Exercise promotes learning and memory formation. These effects depend on increases in
hippocampal BDNF, a growth factor associated with cognitive improvement and the …

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …

Background Metformin, a first-line antiglycemic drug, has been reported to have anti-
depressant effects in patients with type 2 diabetes; however, its exact role and underlying …

Stroke is the second cause of death and more importantly first cause of disability in people
over 40 years of age. Current therapeutic management of ischemic stroke does not provide …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …