Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing
Cognitive ageing research examines the cognitive abilities that are preserved and/or those
that decline with advanced age. There is great individual variability in cognitive ageing …
that decline with advanced age. There is great individual variability in cognitive ageing …
The brain's default network: anatomy, function, and relevance to disease
Thirty years of brain imaging research has converged to define the brain's default network—
a novel and only recently appreciated brain system that participates in internal modes of …
a novel and only recently appreciated brain system that participates in internal modes of …
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
Plasma phospholipids identify antecedent memory impairment in older adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
The evolution of preclinical Alzheimer's disease: implications for prevention trials
As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …
when the pathophysiological process has begun in the brain, but clinical symptoms are not …
The functional role of the precuneus
Recent advancements in computational approaches and neuroimaging techniques have
refined our understanding of the precuneus. While previously believed to be largely a visual …
refined our understanding of the precuneus. While previously believed to be largely a visual …
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …
Brain imaging in Alzheimer disease
Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …
Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …