The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

A variety of physiological death signals, as well as pathological cellular insults, trigger the
genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis …

The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which
translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required …

The proteins of the Bcl-2 family are important regulators of programmed cell death. Structural
studies of Bcl-2 family members have provided many important insights into their molecular …

Multiple signal transduction pathways are capable of modifying BCL-2 family members to
reset susceptibility to apoptosis. We used two-dimensional peptide map** and …

Gain-of-function mutations in the Caenorhabditis elegans gene egl-1 cause the HSN
neurons to undergo programmed cell death. By contrast, a loss-of-function egl-1 mutation …

Abstract The Bcl-2 homology 3 (BH3) domain of prodeath Bcl-2 family members mediates
their interaction with prosurvival Bcl-2 family members and promotes apoptosis. We report …