A perspective on brain-age estimation and its clinical promise

C Gaser, P Kalc, JH Cole - Nature computational science, 2024 - nature.com
Brain-age estimation has gained increased attention in the neuroscientific community owing
to its potential use as a biomarker of brain health. The difference between estimated and …

A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility

RJ Jirsaraie, AJ Gorelik, MM Gatavins, DA Engemann… - Patterns, 2023 - cell.com
Brain aging is a complex, multifaceted process that can be challenging to model in ways that
are accurate and clinically useful. One of the most common approaches has been to apply …

Mind the gap: Performance metric evaluation in brain‐age prediction

AMG de Lange, M Anatürk, J Rokicki… - Human Brain …, 2022 - Wiley Online Library
Estimating age based on neuroimaging‐derived data has become a popular approach to
develo** markers for brain integrity and health. While a variety of machine‐learning …

[HTML][HTML] Deep neural networks learn general and clinically relevant representations of the ageing brain

EH Leonardsen, H Peng, T Kaufmann, I Agartz… - NeuroImage, 2022 - Elsevier
The discrepancy between chronological age and the apparent age of the brain based on
neuroimaging data—the brain age delta—has emerged as a reliable marker of brain health …

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

C Constantinides, LKM Han, C Alloza… - Molecular …, 2023 - nature.com
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments,
age-related chronic disease, and premature mortality. We investigated evidence for …

Individual variations in 'brain age'relate to early-life factors more than to longitudinal brain change

D Vidal-Pineiro, Y Wang, SK Krogsrud, IK Amlien… - elife, 2021 - elifesciences.org
Brain age is a widely used index for quantifying individuals' brain health as deviation from a
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …

Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test–retest reliability of publicly available software packages

RP Dörfel, JM Arenas‐Gomez, PM Fisher… - Human Brain …, 2023 - Wiley Online Library
Brain age prediction algorithms using structural magnetic resonance imaging (MRI) aim to
assess the biological age of the human brain. The difference between a person's …

Deep relation learning for regression and its application to brain age estimation

S He, Y Feng, PE Grant, Y Ou - IEEE transactions on medical …, 2022 - ieeexplore.ieee.org
Most deep learning models for temporal regression directly output the estimation based on
single input images, ignoring the relationships between different images. In this paper, we …

Benchmarking the generalizability of brain age models: challenges posed by scanner variance and prediction bias

RJ Jirsaraie, T Kaufmann, V Bashyam… - Human Brain …, 2023 - Wiley Online Library
Abstract Machine learning has been increasingly applied to neuroimaging data to predict
age, deriving a personalized biomarker with potential clinical applications. The scientific and …

Explainable brain age prediction using covariance neural networks

S Sihag, G Mateos, C McMillan… - Advances in Neural …, 2023 - proceedings.neurips.cc
In computational neuroscience, there has been an increased interest in develo** machine
learning algorithms that leverage brain imaging data to provide estimates of" brain age" for …