FGF/FGFR signaling in health and disease

Y **e, N Su, J Yang, Q Tan, S Huang, M **… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Advances and challenges in targeting FGFR signalling in cancer

IS Babina, NC Turner - Nature Reviews Cancer, 2017 - nature.com
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …

Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy

A Grabner, AP Amaral, K Schramm, S Singh, A Sloan… - Cell metabolism, 2015 - cell.com
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

YK Chae, K Ranganath, PS Hammerman… - …, 2016 - pmc.ncbi.nlm.nih.gov
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …

Fibroblast growth factor signalling: from development to cancer

N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

Fibroblast growth factors and their receptors in cancer

J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

Roles of fibroblast growth factor receptors in carcinogenesis

EM Haugsten, A Wiedlocha, S Olsnes… - Molecular cancer research, 2010 - AACR
The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …

Fibroblast growth factor receptors (FGFRs) and noncanonical partners in cancer signaling

HR Ferguson, MP Smith, C Francavilla - Cells, 2021 - mdpi.com
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …

Effects of nanoplastics and butyl methoxydibenzoylmethane on early zebrafish embryos identified by single-cell RNA sequencing

Y Liu, Y Wang, X Ling, Z Yan, D Wu… - … Science & Technology, 2021 - ACS Publications
Nanoplastics with small particle sizes and high surface area/volume ratios easily absorb
environmental pollutants and affect their bioavailability. In this study, polystyrene nanoplastic …

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

JGT Vi, AT Cheuk, PS Tsang, JY Chung… - The Journal of …, 2009 - Am Soc Clin Investig
Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and
patient survival is poor in the presence of metastatic disease. Few determinants that regulate …