Cognitive impairment associated with schizophrenia: from pathophysiology to treatment

DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology

DC Javitt, SJ Siegel, KM Spencer… - …, 2020 - nature.com
New treatment development for psychiatric disorders depends critically upon the
development of physiological measures that can accurately translate between preclinical …

Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia

D Dong, D Yao, Y Wang, SJ Hong, S Genon… - Psychological …, 2023 - cambridge.org
BackgroundSchizophrenia has been primarily conceptualized as a disorder of high-order
cognitive functions with deficits in executive brain regions. Yet due to the increasing reports …

[HTML][HTML] The P300 as marker of inhibitory control–fact or fiction?

RJ Huster, MS Messel, C Thunberg, L Raud - Cortex, 2020 - Elsevier
Inhibitory control, ie, the ability to stop or suppress actions, thoughts, or memories,
represents a prevalent and popular concept in basic and clinical neuroscience as well as …

[HTML][HTML] Disruptions of hierarchical cortical organization in early psychosis and schizophrenia

A Holmes, PT Levi, YC Chen, S Chopra… - Biological Psychiatry …, 2023 - Elsevier
Background The cerebral cortex is organized hierarchically along an axis that spans
unimodal sensorimotor to transmodal association areas. This hierarchy is often …

It's in the timing: reduced temporal precision in neural activity of schizophrenia

A Wolff, J Gomez-Pilar, J Zhang, J Choueiry… - Cerebral …, 2022 - academic.oup.com
Studies of perception and cognition in schizophrenia (SCZ) show neuronal background
noise (ongoing activity) to intermittently overwhelm the processing of external stimuli. This …

Neural mechanisms of working memory dysfunction in patients with chronic insomnia disorder

L Yang, X **ao, L Yu, Z Shen, Y Luo, G Zhao, Z Dou… - Sleep Medicine, 2023 - Elsevier
Objective This study aimed to investigate the neural mechanisms underlying working
memory impairment in patients with chronic insomnia disorder (CID) using event-related …

Reconsidering electrophysiological markers of response inhibition in light of trigger failures in the stop‐signal task

P Skippen, WR Fulham, PT Michie, D Matzke… - …, 2020 - Wiley Online Library
This study investigates the neural correlates underpinning response inhibition using a
parametric ex‐Gaussian model of stop‐signal task performance, fit with hierarchical …

Widespread intra-and inter-network dysconnectivity among large-scale resting state networks in schizophrenia

B Rong, H Huang, G Gao, L Sun, Y Zhou… - Journal of Clinical …, 2023 - mdpi.com
Schizophrenia is characterized by the distributed dysconnectivity of resting-state multiple
brain networks. However, the abnormalities of intra-and inter-network functional connectivity …

Repetitive transcranial magnetic stimulation promotes response inhibition in patients with major depression during the stop-signal task

F Yu, Y Huang, T Chen, X Wang, Y Guo, Y Fang… - Journal of Psychiatric …, 2022 - Elsevier
Background Response inhibition (RI) deficit is an aspect of cognitive impairment in
depressed individuals, but currently no effective treatment has been established. This study …