Cognitive impairment associated with schizophrenia: from pathophysiology to treatment
DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology
New treatment development for psychiatric disorders depends critically upon the
development of physiological measures that can accurately translate between preclinical …
development of physiological measures that can accurately translate between preclinical …
Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia
BackgroundSchizophrenia has been primarily conceptualized as a disorder of high-order
cognitive functions with deficits in executive brain regions. Yet due to the increasing reports …
cognitive functions with deficits in executive brain regions. Yet due to the increasing reports …
[HTML][HTML] The P300 as marker of inhibitory control–fact or fiction?
Inhibitory control, ie, the ability to stop or suppress actions, thoughts, or memories,
represents a prevalent and popular concept in basic and clinical neuroscience as well as …
represents a prevalent and popular concept in basic and clinical neuroscience as well as …
[HTML][HTML] Disruptions of hierarchical cortical organization in early psychosis and schizophrenia
Background The cerebral cortex is organized hierarchically along an axis that spans
unimodal sensorimotor to transmodal association areas. This hierarchy is often …
unimodal sensorimotor to transmodal association areas. This hierarchy is often …
It's in the timing: reduced temporal precision in neural activity of schizophrenia
Studies of perception and cognition in schizophrenia (SCZ) show neuronal background
noise (ongoing activity) to intermittently overwhelm the processing of external stimuli. This …
noise (ongoing activity) to intermittently overwhelm the processing of external stimuli. This …
Neural mechanisms of working memory dysfunction in patients with chronic insomnia disorder
L Yang, X **ao, L Yu, Z Shen, Y Luo, G Zhao, Z Dou… - Sleep Medicine, 2023 - Elsevier
Objective This study aimed to investigate the neural mechanisms underlying working
memory impairment in patients with chronic insomnia disorder (CID) using event-related …
memory impairment in patients with chronic insomnia disorder (CID) using event-related …
Reconsidering electrophysiological markers of response inhibition in light of trigger failures in the stop‐signal task
This study investigates the neural correlates underpinning response inhibition using a
parametric ex‐Gaussian model of stop‐signal task performance, fit with hierarchical …
parametric ex‐Gaussian model of stop‐signal task performance, fit with hierarchical …
Widespread intra-and inter-network dysconnectivity among large-scale resting state networks in schizophrenia
B Rong, H Huang, G Gao, L Sun, Y Zhou… - Journal of Clinical …, 2023 - mdpi.com
Schizophrenia is characterized by the distributed dysconnectivity of resting-state multiple
brain networks. However, the abnormalities of intra-and inter-network functional connectivity …
brain networks. However, the abnormalities of intra-and inter-network functional connectivity …
Repetitive transcranial magnetic stimulation promotes response inhibition in patients with major depression during the stop-signal task
F Yu, Y Huang, T Chen, X Wang, Y Guo, Y Fang… - Journal of Psychiatric …, 2022 - Elsevier
Background Response inhibition (RI) deficit is an aspect of cognitive impairment in
depressed individuals, but currently no effective treatment has been established. This study …
depressed individuals, but currently no effective treatment has been established. This study …