Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …
elements that have known physiological functions in humans, 12 are metals, including iron …
Manganese-induced parkinsonism and Parkinson's disease: shared and distinguishable features
Manganese (Mn) is an essential trace element necessary for physiological processes that
support development, growth and neuronal function. Secondary to elevated exposure or …
support development, growth and neuronal function. Secondary to elevated exposure or …
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
GK Azad, RS Tomar - Molecular biology reports, 2014 - Springer
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …
multifunctional compound, which catalyzes several essential reactions for the protection of …
Manganese in health and disease
Manganese is an important metal for human health, being absolutely necessary for
development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or …
development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or …
Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative …
D Peng, J Li, Y Deng, X Zhu, L Zhao, Y Zhang… - Journal of …, 2020 - Springer
Background The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-
dependent pyroptosis has been shown to play a vital role in the pathology of manganese …
dependent pyroptosis has been shown to play a vital role in the pathology of manganese …
Sodium para-aminosalicylate delays pericarp browning of litchi fruit by inhibiting ROS-mediated senescence during postharvest storage
The effect of sodium para-aminosalicylate (PAS-Na) on litchi pericarp browning and the
potential regulating mechanism was investigated in this study. Results showed that 0.3 g L …
potential regulating mechanism was investigated in this study. Results showed that 0.3 g L …
Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies
E Pajarillo, I Nyarko-Danquah, A Digman… - Frontiers in …, 2022 - frontiersin.org
Chronic exposure to elevated levels of manganese via occupational or environmental
settings causes a neurological disorder known as manganism, resembling the symptoms of …
settings causes a neurological disorder known as manganism, resembling the symptoms of …
Mechanisms of ebselen as a therapeutic and its pharmacology applications
J Wang, P Wang, C Dong, Y Zhao, J Zhou… - Future medicinal …, 2020 - Taylor & Francis
Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …
Sodium P-aminosalicylic acid inhibits sub-chronic manganese-induced neuroinflammation in rats by modulating MAPK and COX-2
SJ Li, WX Qin, DJ Peng, ZX Yuan, SN He, YN Luo… - Neurotoxicology, 2018 - Elsevier
Excessive manganese (Mn) accumulation in the brain may induce an extrapyramidal
disorder known as manganism. Inflammatory processes play a critical role in …
disorder known as manganism. Inflammatory processes play a critical role in …
Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children
The excess or deficiency of trace metals can cause adverse neurocognitive development.
Evidence of health effect of trace metal mixtures on neurocognitive development is limited in …
Evidence of health effect of trace metal mixtures on neurocognitive development is limited in …