Comparative pathology of aging great apes: bonobos, chimpanzees, gorillas, and orangutans

LJ Lowenstine, R McManamon… - Veterinary …, 2016 - journals.sagepub.com
The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

[HTML][HTML] Nonlinear dynamics of multi-omics profiles during human aging

X Shen, C Wang, X Zhou, W Zhou, D Hornburg, S Wu… - Nature aging, 2024 - nature.com
Aging is a complex process associated with nearly all diseases. Understanding the
molecular changes underlying aging and identifying therapeutic targets for aging-related …

Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies

A Lacreuse, N Raz, D Schmidtke… - … of the Royal …, 2020 - royalsocietypublishing.org
Executive function (EF) is a complex construct that reflects multiple higher-order cognitive
processes such as planning, updating, inhibiting and set-shifting. Decline in these functions …

Prolonged myelination in human neocortical evolution

DJ Miller, T Duka, CD Stimpson… - Proceedings of the …, 2012 - National Acad Sciences
Nerve myelination facilitates saltatory action potential conduction and exhibits
spatiotemporal variation during development associated with the acquisition of behavioral …

Loss of functional GABAA receptors in the Alzheimer diseased brain

A Limon, JM Reyes-Ruiz… - Proceedings of the …, 2012 - National Acad Sciences
The cholinergic and glutamatergic neurotransmission systems are known to be severely
disrupted in Alzheimer's disease (AD). GABAergic neurotransmission, in contrast, is …

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin

DG Peters, JR Connor, MD Meadowcroft - Neurobiology of disease, 2015 - Elsevier
The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …

Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny?

A Watanabe, PM Gignac, AM Balanoff… - Journal of …, 2019 - Wiley Online Library
Cranial endocasts, or the internal molds of the braincase, are a crucial correlate for
investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through …

Brain plasticity and human evolution

CC Sherwood, A Gómez-Robles - annual review of anthropology, 2017 - annualreviews.org
Human behavior is shaped by social learning to an extent that is unrivaled in the natural
world. What neurobiological changes have occurred in human evolutionary history that have …

Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease

MK Edler, CC Sherwood, RS Meindl, WD Hopkins… - Neurobiology of …, 2017 - Elsevier
Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the
accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles …

The value of neuroimaging in dementia diagnosis

CA Raji, TLS Benzinger - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
The Value of Neuroimaging in Dementia Diagnosis : CONTINUUM: Lifelong Learning in
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