Comparative pathology of aging great apes: bonobos, chimpanzees, gorillas, and orangutans
LJ Lowenstine, R McManamon… - Veterinary …, 2016 - journals.sagepub.com
The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …
Despite the many similarities, there are significant differences in aging among apes …
[HTML][HTML] Nonlinear dynamics of multi-omics profiles during human aging
Aging is a complex process associated with nearly all diseases. Understanding the
molecular changes underlying aging and identifying therapeutic targets for aging-related …
molecular changes underlying aging and identifying therapeutic targets for aging-related …
Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies
Executive function (EF) is a complex construct that reflects multiple higher-order cognitive
processes such as planning, updating, inhibiting and set-shifting. Decline in these functions …
processes such as planning, updating, inhibiting and set-shifting. Decline in these functions …
Prolonged myelination in human neocortical evolution
Nerve myelination facilitates saltatory action potential conduction and exhibits
spatiotemporal variation during development associated with the acquisition of behavioral …
spatiotemporal variation during development associated with the acquisition of behavioral …
Loss of functional GABAA receptors in the Alzheimer diseased brain
The cholinergic and glutamatergic neurotransmission systems are known to be severely
disrupted in Alzheimer's disease (AD). GABAergic neurotransmission, in contrast, is …
disrupted in Alzheimer's disease (AD). GABAergic neurotransmission, in contrast, is …
The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin
The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …
Are endocasts good proxies for brain size and shape in archosaurs throughout ontogeny?
Cranial endocasts, or the internal molds of the braincase, are a crucial correlate for
investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through …
investigating the neuroanatomy of extinct vertebrates and tracking brain evolution through …
Brain plasticity and human evolution
Human behavior is shaped by social learning to an extent that is unrivaled in the natural
world. What neurobiological changes have occurred in human evolutionary history that have …
world. What neurobiological changes have occurred in human evolutionary history that have …
Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease
Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the
accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles …
accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles …
The value of neuroimaging in dementia diagnosis
The Value of Neuroimaging in Dementia Diagnosis : CONTINUUM: Lifelong Learning in
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