The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …

Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …

As part of our effort to develop potential tyrosinase inhibitors, we have conjugated the well-
known tyrosinase inhibitor kojic acid (KA) with several phenolic natural products such as …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

Genome mining in association with the OSMAC (one strain, many compounds) approach
provides a feasible strategy to extend the chemical diversity and novelty of natural products …

Gastric cancer is a severe malignant tumor with high morbidity and mortality, which seriously
affects people's health. At present, the most common treatment for gastric cancer is …

One of the main current strategies for cancer treatment is represented by combination
chemotherapy. More recently, this strategy shifted to the “hybrid strategy”, namely the …

In an effort to develop new compounds for managing drug-induced liver injury, we prepared
23 novel hybrids based on 3-acetyl-11-keto-β-boswellic acid (AKBA) using various …

Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …

Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were
designed, synthesized. The antiproliferative activity against lung cancer cell lines including …