Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Endophytic fungi: from symbiosis to secondary metabolite communications or vice versa?
B Alam, J Lǐ, Q Gě, MA Khan, J Gōng… - Frontiers in Plant …, 2021 - frontiersin.org
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …
Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …
the living beings chemistry. However, identification of drugable molecules within the …
A comparative genomics study of 23 Aspergillus species from section Flavi
I Kjærbølling, T Vesth, JC Frisvad, JL Nybo… - Nature …, 2020 - nature.com
Section Flavi encompasses both harmful and beneficial Aspergillus species, such as
Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus …
Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus …
Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri
TC Vesth, JL Nybo, S Theobald, JC Frisvad… - Nature Genetics, 2018 - nature.com
Aspergillus section Nigri comprises filamentous fungi relevant to biomedicine, bioenergy,
health, and biotechnology. To learn more about what genetically sets these species apart …
health, and biotechnology. To learn more about what genetically sets these species apart …
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …
Species include those with industrial applications, important pathogens of humans, animals …
The birth, evolution and death of metabolic gene clusters in fungi
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …
involved in ecologically specialized or accessory functions. Genes in these pathways are …
Dereplication: racing to speed up the natural products discovery process
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …