Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Endophytic fungi: from symbiosis to secondary metabolite communications or vice versa?

B Alam, J Lǐ, Q Gě, MA Khan, J Gōng… - Frontiers in Plant …, 2021 - frontiersin.org
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

The evolution of genome mining in microbes–a review

N Ziemert, M Alanjary, T Weber - Natural product reports, 2016 - pubs.rsc.org
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?

J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …

A comparative genomics study of 23 Aspergillus species from section Flavi

I Kjærbølling, T Vesth, JC Frisvad, JL Nybo… - Nature …, 2020 - nature.com
Section Flavi encompasses both harmful and beneficial Aspergillus species, such as
Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus …

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

TC Vesth, JL Nybo, S Theobald, JC Frisvad… - Nature Genetics, 2018 - nature.com
Aspergillus section Nigri comprises filamentous fungi relevant to biomedicine, bioenergy,
health, and biotechnology. To learn more about what genetically sets these species apart …

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

RP De Vries, R Riley, A Wiebenga, G Aguilar-Osorio… - Genome biology, 2017 - Springer
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

The birth, evolution and death of metabolic gene clusters in fungi

A Rokas, JH Wisecaver, AL Lind - Nature Reviews Microbiology, 2018 - nature.com
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

Dereplication: racing to speed up the natural products discovery process

SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …