In recent years, the role of optically sensitive nanomaterials has become powerful moieties
in therapeutic techniques and has become particularly emphasized. Currently, by the …

Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed
with tight junctions and adherent junctions that regulates the transport of various materials …

The cerebrovascular-specific molecular mechanism in Alzheimer's disease (AD) was
investigated by employing comprehensive and accurate quantitative proteomics. Highly …

One of the major reasons why depressed patients fail their treatment course is the existence
of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central …

Breast cancer is the most common cancer in women and the second leading cause of
cancer‐related deaths after lung cancer. Metastasis of the central nervous system is a …

Purpose: We evaluated the properties and activity of AZD9574, a blood–brain barrier (BBB)
penetrant selective inhibitor of PARP1, and assessed its efficacy and safety alone and in …

Cancer represents one of the most pernicious public health problems with a high mortality
rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches …

As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …