Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
XPO1-dependent nuclear export as a target for cancer therapy
NG Azizian, Y Li - Journal of hematology & oncology, 2020 - Springer
Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …
Micronuclear collapse from oxidative damage
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei
frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol …
frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol …
Explaining decisions of graph convolutional neural networks: patient-specific molecular subnetworks responsible for metastasis prediction in breast cancer
H Chereda, A Bleckmann, K Menck, J Perera-Bel… - Genome medicine, 2021 - Springer
Background Contemporary deep learning approaches show cutting-edge performance in a
variety of complex prediction tasks. Nonetheless, the application of deep learning in …
variety of complex prediction tasks. Nonetheless, the application of deep learning in …
PANoptosis: Mechanisms, biology, and role in disease
X Sun, Y Yang, X Meng, J Li, X Liu… - Immunological …, 2024 - Wiley Online Library
Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin's lymphoma and facilitates ultrasensitive residual disease detection
S Sobesky, L Mammadova, M Cirillo, EEE Drees… - Med, 2021 - cell.com
Background Individualization of treatment in Hodgkin's lymphoma is necessary to improve
cure rates and reduce treatment side effects. Currently, it is hindered by a lack of genomic …
cure rates and reduce treatment side effects. Currently, it is hindered by a lack of genomic …
[HTML][HTML] E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1
B Kwanten, T Deconick, C Walker, F Wang… - Biomedicine & …, 2023 - Elsevier
Abstract Selinexor (KPT-330), a small-molecule inhibitor of exportin-1 (XPO1, CRM1) with
potent anticancer activity, has recently been granted FDA approval for treatment of …
potent anticancer activity, has recently been granted FDA approval for treatment of …
[HTML][HTML] A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
G Lazarian, S Yin, E Ten Hacken, T Sewastianik… - Cancer Cell, 2021 - cell.com
Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic
lymphocytic leukemia (CLL), but its function remains unknown. Here, we demonstrate its …
lymphocytic leukemia (CLL), but its function remains unknown. Here, we demonstrate its …
RNA-binding proteins of COSMIC importance in cancer
Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the
National Human Genome Research Institute to sequence thousands of tumors representing …
National Human Genome Research Institute to sequence thousands of tumors representing …