The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

Abstract Interleukin-1β (IL-1β) belongs to IL-1 family and is a potent pro-inflammatory
cytokine. It is known to be also involved in a variety of cellular activities, including cell …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …

Osteoarthritis is a degenerative joint disease characterized by a progressive and irreversible
loss of the articular cartilage, due in main part to the cleavage of type II collagen within the …

Objective. Trans‐cinnamaldehyde (TCA), a compound from Cinnamomum cassia Presl, has
been reported to have anti‐inflammatory effect. However, its effect on cartilage degradation …

Irreversible breakdown of cartilage extracellular matrix (ECM) by the collagenase matrix
metalloproteinase 13 (MMP13) represents a key event in osteoarthritis (OA) progression …

Metalloproteinases remain important players in arthritic disease, in part because members
of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are …

Osteoarthritis (OA) is one of the most prevalent causes of joint disease. However, the
pathological mechanisms of OA have remained to be completely elucidated, and further …

Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to
photoaging, inflammation, immune suppression and tumour formation. A recent report has …

HLA-G is an immune checkpoint molecule with specific relevance in cancer immunotherapy.
It was first identified in cytotrophoblasts, protecting the fetus from maternal rejection. HLA-G …