Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

As one of the highest energy consumer organ in mammals, the heart has to be provided with
a high amount of energy as soon as its first beats in utero. During the development of this …

The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then
throughout the embryo to establish circulatory networks that further acquire organ-specific …

Enhancers are distal regulatory elements that can activate tissue-specific gene expression
and are abundant throughout mammalian genomes. Although substantial progress has …

Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells,
thought to arise from distinct embryonic precursors. We use genetic fate-map** studies to …

The vertebrate heart arises from the fusion of bilateral regions of anterior mesoderm to form
a linear heart tube. Recent studies in mouse and chick have demonstrated that a second …

Congenital heart disease is a major cause of morbidity and mortality throughout life.
Mutations in numerous transcription factors have been identified in patients and families with …