Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of
pharmacological agents and can lead to disease progression. Cold atmospheric plasma …

Background Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and
pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play …

Hydrogel-based 3D in vitro models comprising tumor ECM-mimetic biomaterials exhibit
superlative potential as preclinical testing platforms for drug discovery and bioperformance …

The failure of the osteosarcoma conventional therapies leads to the growing need for novel
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …

High-dose systemic chemotherapy constitutes a main strategy in the management of bone
metastases, employing drugs like doxorubicin (DOX), related with severe side effects. To …

Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and
adolescents. While numerous other cancers now have promising therapeutic advances …

Osteosarcoma is the most common primary bone tumor, and its first line of treatment
presents a high failure rate. The 5-year survival for children and teenagers with …

Osteosarcoma (OS) is a malignant type of bone cancer that arises in periods of increased
bone formation. Curative strategies for these types of tumors have remained essentially …