Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …

There is now very persuasive evidence that the transmissible agent for spongiform
encephalopathies such as scrapie, consists of a modified form of the normal host protein …

Transgenic (Tg) mice expressing both Syrian hamster (Ha) and mouse (Mo) prion protein
(PrP) genes were used to probe the mechanism of scrapie prion replication. Four Tg lines …

Scrapie and related transmissible spongiform encephalopathies result in the accumulation
of a protease-resistant form of an endogenous brain protein called PrP. As an approach to …

Numerous studies have indicated that a modified proteinase K-resistant form of an
endogenous brain protein, prion protein (PrP), is associated with scrapie infection in …

A mouse neuroblastoma cell line was successfully infected with scrapie agent. Agent
derived from infected mouse brain or spleen infected cultures. However, agent from infected …

Prions are unusual infectious pathogens causing scrapie of sheep and goats as well as
Creutzfeldt-Jakob disease of humans. Biochemical and genetic studies contend that the …

Prions are infectious proteins that have been implicated in various human diseases such as
Gertsmann-Straussler-Scheinker disease, Creutzfeldt-Jacob disease and Kuru disease. The …

A human complementary DNA whose protein product is considered to be the major
component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann …

Enriching fractions from Syrian hamster (SHa) brain for scrapie prion infectivity led to the
discovery of the prion protein (PrP). Prion diseases include scrapie of sheep and bovine …