In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

Although population-level analyses revealed significant roles for CTCF and cohesin in
mammalian genome organization, their contributions at the single-cell level remain …

Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily
conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but …

Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …

Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Regulation of gene expression is a complex but highly guided process. While genomic
technologies and computational approaches have allowed high-throughput map** of cis …

Hi-C, split-pool recognition of interactions by tag extension (SPRITE) and genome
architecture map** (GAM) are powerful technologies utilized to probe chromatin …