Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

As natural living substances, microorganisms have emerged as useful resources in
medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The …

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer has a high
metastatic potential. Monoclonal antibodies (mAbs) that target HER2, such as trastuzumab …

The cell cycle is the series of events that occur in a cell leading to its division and
duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the …

Highlights•Serum albumin (SA) enhances pharmacokinetic properties of small
immunomodulatory payloads (IMMs).•SA can traffic efficiently to the lymphatics and thus …

Acute kidney injury (AKI) is associated with immune cell activation and inflammation.
However, the putative pathogenic mechanisms of this injury have not been thoroughly …

Breast cancer poses one of the largest threats to women's health. Treatment continues to
improve for all the subtypes of breast cancer, but some subtypes, such as triple negative …

The evolutionary conserved DNA-sensing cGAS-STING innate immunity pathway represents
one of the most important cytosolic DNA-sensing systems that is activated in response to …

Cancer immunoediting is a dynamic process of tumor-immune system interaction that plays
a critical role in cancer development and progression. Recent studies have highlighted the …