Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

Adaptive mechanisms of plant specialized metabolism connecting chemistry to function

JK Weng, JH Lynch, JO Matos, N Dudareva - Nature Chemical Biology, 2021 - nature.com
As sessile organisms, plants evolved elaborate metabolic systems that produce a plethora of
specialized metabolites as a means to survive challenging terrestrial environments …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

Exploring uncharted territories of plant specialized metabolism in the postgenomic era

JR Jacobowitz, JK Weng - Annual review of plant biology, 2020 - annualreviews.org
For millennia, humans have used plants for food, raw materials, and medicines, but only
within the past two centuries have we begun to connect particular plant metabolites with …

Artificial intelligence in microbial natural product drug discovery: current and emerging role

VJ Sahayasheela, MB Lankadasari, VM Dan… - Natural product …, 2022 - pubs.rsc.org
Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …

Exploring microbial community structure and metabolic gene clusters during silage fermentation of paper mulberry, a high-protein woody plant

Z Du, L Sun, C Chen, J Lin, F Yang, Y Cai - Animal Feed Science and …, 2021 - Elsevier
To develop a new high-protein woody forage resource for livestock to alleviate feed
shortages in the tropics, we applied PacBio single-molecule, real-time (SMRT) sequencing …

Omics-guided metabolic pathway discovery in plants: Resources, approaches, and opportunities

K Zhao, SY Rhee - Current opinion in plant biology, 2022 - Elsevier
Plants produce a vast array of metabolites, the biosynthetic routes of which remain largely
undetermined. Genome-scale enzyme and pathway annotations and omics technologies …

[HTML][HTML] New and emerging concepts in the evolution and function of plant biosynthetic gene clusters

G Polturak, Z Liu, A Osbourn - Current Opinion in Green and Sustainable …, 2022 - Elsevier
Plants are a rich source of diverse chemicals. Metabolic diversification is likely a reflection of
adaptation to particular environmental niches because many of these compounds are …

Effective clustering via structured graph learning

D Wu, F Nie, J Lu, R Wang, X Li - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Given an affinity graph of data samples, graph-based clustering aims to partition these
samples into disjoint groups based on the affinities, and most previous works are based on …

Colocality to cofunctionality: eukaryotic gene neighborhoods as a resource for function discovery

F Foflonker, CE Blaby-Haas - Molecular Biology and Evolution, 2021 - academic.oup.com
Diverging from the classic paradigm of random gene order in eukaryotes, gene proximity
can be leveraged to systematically identify functionally related gene neighborhoods in …